2-METHYL-4-PHENYL-2-BUTANOL synthesis
- Product Name:2-METHYL-4-PHENYL-2-BUTANOL
- CAS Number:103-05-9
- Molecular formula:C11H16O
- Molecular Weight:164.24
2550-26-7
385 suppliers
$9.00/100g
676-58-4
290 suppliers
$15.00/25ml
103-05-9
209 suppliers
$43.00/25g
Yield:103-05-9 72%
Reaction Conditions:
in tetrahydrofuran at 0; for 0.166667 h;Inert atmosphere;
Steps:
Synthesis of 2-methyl-4-phenylbutan-2-ol (25)
To a solution of S13 (1.00 mL, 6.68 mmol) in THF (33 mL) was added 3.0 M THF solution of MeMgCl (3.34 mL, 10.0 mmol) at 0 °C, and the mixture was stirred for 10 minutes. The reaction was quenched with saturated aqueous solution of NH4Cl, and the mixture was extracted with AcOEt (x3). The combined organic layers were washed with brine, dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography (Hexane/AcOEt = 4/1) to give 25 (786 mg, 4.79 mmol, 72%) as a colorless oil. 1H NMR (500 MHz, CDCl3): δ 7.34-7.20 (m, 5H), 2.71-2.67 (m, 2H), 1.80 (d, J = 17.4 Hz, 1H), 1.78-1.74 (m, 2H), 1.27 (s, 6H). This 1H NMR data is identical with that of ref 6.
References:
Tsutsumi, Tomohiro;Saitoh, Arisa;Kasai, Tomoyo;Chu, MengYue;Karanjit, Sangita;Nakayama, Atsushi;Namba, Kosuke [Tetrahedron Letters,2020,vol. 61,# 26,art. no. 152047] Location in patent:supporting information
558-30-5
244 suppliers
$20.00/5 g
1589-82-8
165 suppliers
$60.00/5g
103-05-9
209 suppliers
$43.00/25g
558-30-5
244 suppliers
$20.00/5 g
100-39-0
431 suppliers
$10.00/10 g
103-05-9
209 suppliers
$43.00/25g
292638-84-7
0 suppliers
inquiry
67-63-0
1688 suppliers
$16.00/25ML
103-05-9
209 suppliers
$43.00/25g
13667-12-4
74 suppliers
$32.00/250mg
13041-70-8
32 suppliers
$15.00/250mg
103-05-9
209 suppliers
$43.00/25g