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ChemicalBook CAS DataBase List 2-Octyl-2H-isothiazol-3-one
26530-20-1

2-Octyl-2H-isothiazol-3-one synthesis

5synthesis methods
2-Octyl-2H-isothiazol-3-one is a new type of high-efficiency broad-spectrum fungicide, which is widely used in cosmetics, coatings, adhesives, building materials, textiles, fabrics, medical and health care and other fields. 2-Octyl-2H-isothiazol-3-one is prepared from N,N'-Di-n-octyl-3,3'-dithiodipropionaMide and Chlorine by stirring in Ethyl acetate for 3.5 h at room temperature.
-

Yield:26530-20-1 71%

Reaction Conditions:

in dichloromethane

Steps:

W.4 (Working Example 4)
(Working Example 4) A reaction was carried out under the same conditions as in Working Example 1 except for the use of N,N'-di-n-octyl-3,3'-dithiopropionamide as the starting material, and using dichloromethane as the reaction solvent and using monochlorobenzene in washing the hydrochloride salt, and 2-n-octyl-4-isothiazoline-3-one was obtained in 71% yield.

References:

Chemicrea Inc. EP1113012, 2001, A1

FullText

33312-01-5 Synthesis
3,3'-Dithiobis(N-octylpropionamide)

33312-01-5
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64359-81-5 Synthesis
4,5-Dichloro-2-octyl-isothiazolone

64359-81-5
286 suppliers
$6.00/1g

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