4,5-Dichloro-2-octyl-isothiazolone synthesis
- Product Name:4,5-Dichloro-2-octyl-isothiazolone
- CAS Number:64359-81-5
- Molecular formula:C11H17Cl2NOS
- Molecular Weight:282.23
33312-01-5
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64359-81-5
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Yield:64359-81-5 91%
Reaction Conditions:
with trichlorophosphate in acetic acid butyl ester at 10 - 40; for 2 h;Temperature;
Steps:
1-4
Add 200 mL of butyl acetate into a round bottom flask with an exhaust gas absorption device, then add the above intermediate 3,3'-dithiodioctylpropionamide, and slowly drop 100 g of phosphorus oxychloride at 10°C. After the dripping is completed and the gas no longer comes out, the ice bath is removed, and the temperature is raised to 40° C. to continue the reaction for 2 hours. After the reaction, the reactor was cooled to 5°C, and 5% sodium bicarbonate solution was slowly dropped to neutrality. After separating the water layer, the solvent was dried off and recrystallized with methanol to obtain a white solid.It is 4,5-dichloro-2-n-octyl-3-isothiazolinone, the solid weight is 94.55g, the yield is 91%,
References:
CN113582941,2021,A Location in patent:Paragraph 0032-0033; 0035; 0036; 0038; 0039; 0041; 0042; ...
26530-20-1
305 suppliers
$38.00/1g
64359-81-5
288 suppliers
$6.00/1g
33312-01-5
33 suppliers
inquiry
64359-81-5
288 suppliers
$6.00/1g
26530-20-1
305 suppliers
$38.00/1g