2-Octylbenzimidazole synthesis
- Product Name:2-Octylbenzimidazole
- CAS Number:13060-24-7
- Molecular formula:C15H22N2
- Molecular Weight:230.35
Yield: 86%
Reaction Conditions:
with choline chloride;oxalic acid at 30; for 7 h;
Steps:
3 Synthesis of 2-n-octylbenzimidazole
To the eutectic solvent (70g) composed of choline chloride and oxalic acid (molar ratio 1:2), add o-phenylenediamine (54g, 0.5mol) and n-nonanal (85g, 0.6mol) at 30°C React at constant temperature for 7 hours (use silica gel chromatography (TLC) to monitor the reaction).After the reaction is completed, cold water (400 mL) is added, the precipitated solid is filtered, washed with water, and dried.The crude product was recrystallized with ethanol to obtain off-white crystals (90 g) with a yield of 86%.
References:
CN113620886, 2021, A Location in patent:Paragraph 0041-0046
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