2-Thiopheneacetonitrile synthesis
- Product Name:2-Thiopheneacetonitrile
- CAS Number:20893-30-5
- Molecular formula:C6H5NS
- Molecular Weight:123.18
765-50-4
106 suppliers
$166.94/1G
7677-24-9
389 suppliers
$19.00/5g
20893-30-5
200 suppliers
$9.00/1g
Yield:20893-30-5 98%
Reaction Conditions:
with potassium carbonate in acetonitrile at 70; for 10 h;
Steps:
1 Example 1 Preparation of Thiophene-2-acetonitrile (I)
Take 2-chloromethyl thiophene 132g, dissolved in 500 ml of acetonitrile, add 150g of potassium carbonate, add 110g of trimethylsilyl cyanide in batches, after the addition, the reaction system was heated to 70 ° C reaction 10h, after the reaction was completed, cooled to At room temperature, the filtrate was filtered, the filtrate was recovered under reduced pressure in acetonitrile, the residue was added with 300 ml of toluene, and 200 ml of 1N NaOH solution was added to the system. The liquid was separated, and the organic layer was added to 1N.NaOH solution 100 ml, liquid separation, washed with water to neutrality, dried over anhydrous magnesium sulfate, filtered, and the filtrate was recovered under reduced pressure. The residue was distilled under reduced pressure to obtain 120 g of pale yellow liquid with a yield of 98%.
References:
Jiangsu Engineering Polytechnic College;Feng Chengliang;Yan Bin CN107698554, 2018, A Location in patent:Paragraph 0039; 0040
4461-29-4
69 suppliers
$22.80/5g
20893-30-5
200 suppliers
$9.00/1g
