2-Trifluoromethoxyphenol synthesis
- Product Name:2-Trifluoromethoxyphenol
- CAS Number:32858-93-8
- Molecular formula:C7H5F3O2
- Molecular Weight:178.11
456-55-3
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$6.00/10g
32858-93-8
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$10.00/1g
Yield:32858-93-8 88%
Reaction Conditions:
Stage #1:1-trifluoromethoxybenzene with N,N,N,N,-tetramethylethylenediamine;sec.-butyllithium in tetrahydrofuran;cyclohexane at -75; for 2 h;
Stage #2: with fluorodimethoxyborane diethyl etherate in tetrahydrofuran;cyclohexane at -75;
Stage #3: with sodium hydroxide;dihydrogen peroxide in tetrahydrofuran;cyclohexaneFurther stages.;
References:
Castagnetti, Eva;Schlosser, Manfred [European Journal of Organic Chemistry,2001,# 4,p. 691 - 695]