3,5-Dihydroxybenzaldehyde synthesis
- Product Name:3,5-Dihydroxybenzaldehyde
- CAS Number:26153-38-8
- Molecular formula:C7H6O3
- Molecular Weight:138.12
29654-55-5
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26153-38-8
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Yield:26153-38-8 80%
Reaction Conditions:
with chromium(VI) oxide;sulfuric acid in tetrahydrofuran at 0; for 2.5 h;
Steps:
1.2
Step 2, adding concentrated sulfuric acid (1.5 kg) to a solution of saturated chromium trioxide (770 g) to prepare a Jones reagent;The intermediate B (770 g) in tetrahydrofuran (1 kg) was cooled to 0 ° C.Adding the prepared Jones reagent to it,Adding time 0.5 hours,Stirring at 0 ° C for 2 hours;After the reaction was completed, a saturated sodium hydrogencarbonate solution (3 kg) was added dropwise thereto at 0 ° C until no bubbles were formed.Ethyl acetate (2 kg) was further added thereto, stirred for 0.5 hour, and filtered to obtain a filtrate;The filtrate was extracted three times with deionized water (1 kg each time) and the aqueous phase was extracted once more with ethyl acetate (2 kg).Combine the organic phases with a rotary evaporator,Drying at 45 ° C to give a brown solid C ( 610 g).Yield 80%
References:
CN110256214,2019,A Location in patent:Paragraph 0030-0034; 0038
7311-34-4
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26153-38-8
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39192-49-9
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26153-38-8
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856077-23-1
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26153-38-8
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99-10-5
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26153-38-8
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