3-Amino-4-fluorophenol synthesis
- Product Name:3-Amino-4-fluorophenol
- CAS Number:62257-16-3
- Molecular formula:C6H6FNO
- Molecular Weight:127.12
2105-96-6
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62257-16-3
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Yield: 90%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in ethanol at 20; under 760.051 Torr; for 18 h;
Steps:
Step 1 . Synthesis of compound (233)
Palladium on activated charcoal (around 300mg) was added to a solution of 4-fluoro-3-nitro-phenol 232 (3.0g, 19.0mmol, 1 .Oeq) in ethanol (1 OOmL). The reaction mixture was hydrogenated at room temperature over 1 atmosphere of hydrogen for 18h. The reaction mixture was filtrated through a short pad of celite and rinsed with ethanol. The filtrate was evaporated to dryness to afford the expected compound 233 as brown sticky solid (Yield: 90%, 2.18g). The compound was used directly in the next step without further purification.
References:
ANAGENESIS BIOTECHNOLOGIES S.A.S. WO2021/13712, 2021, A1 Location in patent:Page/Page column 152
84478-75-1
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62257-16-3
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75001-47-7
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62257-16-3
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62257-16-3
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84478-72-8
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