3-HYDROXYBUTYRONITRILE synthesis
- Product Name:3-HYDROXYBUTYRONITRILE
- CAS Number:4368-06-3
- Molecular formula:C4H7NO
- Molecular Weight:85.1
5977-14-0
197 suppliers
$35.70/100g
4368-06-3
37 suppliers
$150.00/1g
Yield: 85 %Chromat.
Reaction Conditions:
with Triethoxysilane;[cis-Fe(H)(SPh)(PMe3)4] in tetrahydrofuran at 60; for 24 h;Inert atmosphere;
Steps:
2.2. General procedure for the dehydration of amides to nitriles
General procedure: To a 25ml Schlenk tube containing a solution of 1 in 2ml of THF was added amide (1.0 mmol) and (EtO)3SiH (0.50 g, 3.0 mmol). The reaction mixture was stirred at 60 °C until there was no amide left (monitored by TLC and GC-MS). The product was purified according to literature procedures by Beller [27].
References:
Xue, Benjing;Sun, Hongjian;Wang, Yan;Zheng, Tingting;Li, Xiaoyan;Fuhr, Olaf;Fenske, Dieter [Catalysis Communications,2016,vol. 86,p. 148 - 150]
75-07-0
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$14.00/5mL
75-05-8
1057 suppliers
$10.00/10g
4368-06-3
37 suppliers
$150.00/1g
141-78-6
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$20.50/250ml
75-05-8
1057 suppliers
$10.00/10g
4368-06-3
37 suppliers
$150.00/1g
127-00-4
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$25.19/25g
4368-06-3
37 suppliers
$150.00/1g
4786-20-3
80 suppliers
$9.00/1g
4368-06-3
37 suppliers
$150.00/1g