3-(Trifluoromethoxy)fluorobenzene synthesis
- Product Name:3-(Trifluoromethoxy)fluorobenzene
- CAS Number:1077-01-6
- Molecular formula:C7H4F4O
- Molecular Weight:180.1
372-20-3
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1077-01-6
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: sodium hydride / 1,4-dioxane / Inert atmosphere; Schlenk technique; Reflux
1.2: 0 °C / Inert atmosphere; Schlenk technique; Reflux
2.1: Selectfluor; silver trifluoromethanesulfonate; phosphoric acid / dichloromethane; water / 1 h / 55 °C / Inert atmosphere; Glovebox
References:
Krishanmoorthy, Sankarganesh;Schnell, Simon D.;Dang, Huong;Fu, Fang;Prakash, G.K. Surya [Journal of Fluorine Chemistry,2017,vol. 203,p. 130 - 135]