ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE synthesis
- Product Name:ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE
- CAS Number:313967-69-0
- Molecular formula:C15H16N2O5
- Molecular Weight:304.3
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Yield:-
Reaction Conditions:
with ammonium acetate;acetic acid at 80; for 10 h;
Steps:
General procedure for the synthesis of 5-carboethoxy-2-oxo-1,2,3,4-tetrahydropyridines (1a-1h)
General procedure: 4-aryl substituted5-carboethoxy-2-oxo-1,2,3,4-tetrahydropyridines(THPYs) considered for the present study were synthesizedaccording to the reported procedure [25]. In a typicalmethod, a mixture of Meldrum’s acid (1 mmol), aromaticaldehyde (1 mmol), ethyl acetoacetate (1 mmol) andammonium acetate (2.5 mmol) in 0.5 mL glacial acetic acidwas heated at 80 °C for 10 h. Subsequently, the mixturewas added to ice water; then, the precipitated compoundwas collected and purified by recrystallization from methanolto obtain pure product.
References:
Memarian, Hamid Reza;Kalantari, Mahdieh [Journal of the Iranian Chemical Society,2017,vol. 14,# 1,p. 143 - 155]