4-Amino-3,5-dichloroacetophenone synthesis
- Product Name:4-Amino-3,5-dichloroacetophenone
- CAS Number:37148-48-4
- Molecular formula:C8H7Cl2NO
- Molecular Weight:204.05
75-36-5
579 suppliers
$17.92/100G
608-31-1
312 suppliers
$12.00/25g
37148-48-4
376 suppliers
$6.00/1g
Yield:37148-48-4 88.6%
Reaction Conditions:
with iron(III) chloride in chloroform at 0 - 20; for 6 h;
Steps:
2.1 Preparation of 3,5-dichloro-4-aminoacetophenone
A 250 mL three-necked flask was charged with 8.3 g of 2,6-dichloroaniline,After adding 50 mL of chloroform and stirring to disperse,Add ferric chloride 30g,Control temperature 0 ° C was added dropwise acetyl chloride 8.8g,After completion of the dropwise addition at room temperature for 6 hours,After acidification,Suction filtration,Washed with water to give 9.0 g of light yellow 3,5-dichloro-4-aminoacetophenone,Yield 88.6%, HPLCTesting, purity 99.5%
References:
Shanghai Chemical Institute;Xu Zhongjie;Luo Yong;Sun Kai;Yang Weicheng;Sun Wen;Li Meihua;Tu Yahui;Zhong Jiaqi;Fang Chao CN105968021, 2016, A Location in patent:Paragraph 0168-0169
99-92-3
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6953-83-9
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$170.00/50 mg
37148-48-4
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$6.00/1g
108-24-7
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$14.00/250ML
608-31-1
312 suppliers
$12.00/25g
37148-48-4
376 suppliers
$6.00/1g
99-92-3
531 suppliers
$6.00/10g
37148-48-4
376 suppliers
$6.00/1g
7782-50-5
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$373.00/454g
99-92-3
531 suppliers
$6.00/10g
64-19-7
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$10.00/25ML
37148-48-4
376 suppliers
$6.00/1g
634-93-5
224 suppliers
$12.00/5g