4-Ethynyltoluene synthesis
- Product Name:4-Ethynyltoluene
- CAS Number:766-97-2
- Molecular formula:C9H8
- Molecular Weight:116.16
4186-14-5
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766-97-2
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Yield:766-97-2 95%
Reaction Conditions:
with potassium trimethylsilonate in dimethyl sulfoxide at 60; under 760.051 Torr; for 6 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Solvent;
Steps:
19
4-[(trimethylsilyl)ethynyl]toluene (1 mmol), inorganic base potassium tert-butoxide (sodium) or potassium hydroxide (sodium) or potassium trimethylsilylate (sodium) (0.05 mmol), 2 mL of DMA or DMSO solvent was sequentially added to a 10 mL sealed tube and heated and stirred in a 60° C. oil bath for 6 hours. The progress of the reaction was followed by TLC. The reaction was completed and an equivalent of mesitylene or n-undecane was added to the crude product. The exact yield of the product was determined by GC and GC-MS. According to GC and GC-MS, when DMSO is used as a reaction solvent, inorganic base potassium tert-butoxide (sodium) or potassium hydroxide (sodium) or potassium trimethylsilylate (sodium) is used as a catalyst, and the yields of the products are as follows: : 72%, 71%, 77%, 82%, 95%, 91%. When DMA was used as the reaction solvent, the inorganic potassium tert-butoxide (sodium) or potassium hydroxide (sodium) or potassium trimethylsilylate (sodium) was used as the catalyst. The yield of the product was: 63%, 62%, respectively. 66%, 70%, 85%, 79%.
References:
Taizhou University;Yao Wubing CN107459438, 2017, A Location in patent:Paragraph 0052; 0053
33458-08-1
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766-97-2
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73839-44-8
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766-97-2
230 suppliers
$6.00/1g