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ChemicalBook CAS DataBase List 4-Fluoro-2-methoxyphenol
450-93-1

4-Fluoro-2-methoxyphenol synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: 100 percent / K2CO3 / dimethylsulfoxide / 2 h / 20 °C
2.1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide; m-CPBA / CH2Cl2 / Heating
2.2: 71 percent / aq. NaOH / ethanol / 2 h

References:

Mewshaw, Richard E.;Zhou, Dahui;Zhou, Ping;Shi, Xiaojie;Hornby, Geoffrey;Spangler, Taylor;Scerni, Rosemary;Smith, Deborah;Schechter, Lee E.;Andree, Terrance H. [Journal of Medicinal Chemistry,2004,vol. 47,# 15,p. 3823 - 3842]

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