4-Fluoro-2-nitrotoluene synthesis
- Product Name:4-Fluoro-2-nitrotoluene
- CAS Number:446-10-6
- Molecular formula:C7H6FNO2
- Molecular Weight:155.13
850462-64-5
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$11.00/250mg
446-10-6
347 suppliers
$10.00/25g
Yield:446-10-6 91%
Reaction Conditions:
with sulfolane;sodium hydrogencarbonate at 195; for 2 h;
Steps:
11 Preparation of 2-methyl-5-fluoronitrobenzene
2.0 kg of sulfolane was added to the reaction vessel, and 199 g (1 mol) of 2-methyl-5-fluoro-3-nitrobenzoic acid and 168 g (2 mol) of sodium hydrogencarbonate were successively added, and the reaction vessel was heated to 195 ° C for 2 h. . After the completion of the reaction, the temperature of the reaction vessel was lowered to about 130 ° C, and the solvent was evaporated under reduced pressure, followed by distillation to give 141 g of the desired compound as a pale yellow liquid, yield 91%.
References:
CN109467509,2019,A Location in patent:Paragraph 0066-0069
352-32-9
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446-10-6
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$10.00/25g
119-32-4
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446-10-6
347 suppliers
$10.00/25g
352-32-9
317 suppliers
$9.00/5g
119-33-5
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446-10-6
347 suppliers
$10.00/25g
446-11-7
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$20.00/10g
64-19-7
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