4-FLUORO-3-NITROBENZONITRILE synthesis
- Product Name:4-FLUORO-3-NITROBENZONITRILE
- CAS Number:1009-35-4
- Molecular formula:C7H3FN2O2
- Molecular Weight:166.11
1194-02-1
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1009-35-4
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$8.00/1g
Yield:-
Reaction Conditions:
with sulfuric acid;potassium nitrate
Steps:
V.1 Step 1.
Step 1. 4-Fluoro-3-nitrobenzonitrile. The largest amount of silica gel that still allowed the resulting slurry to be stirred magnetically at 0° C., was added to conc. sulfuric acid (125 ml). To this mixture 4-fluorobenzonitrile (12.5 g, 103 mmol) was added followed by potassium nitrate (10.4 g, 103 mmol). The reaction mixture was stirred at 0° C. for 20 minutes. The sulfuric acid was removed from the product by passing the mixture through a short column of silica gel and the product was washed out with methylene chloride. The solvent was evaporated to leave the product as a crystalline solid. Yield 6.0 g, mp 86°-88° C.
References:
US5360809,1994,A
939-80-0
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1009-35-4
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$8.00/1g
42564-51-2
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1009-35-4
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$8.00/1g
939-80-0
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3272-08-0
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$12.00/5g
1009-35-4
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$8.00/1g
64248-62-0
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$6.00/5g