4-Fluorobenzylamine synthesis
- Product Name:4-Fluorobenzylamine
- CAS Number:140-75-0
- Molecular formula:C7H8FN
- Molecular Weight:125.14
318-49-0
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140-75-0
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$10.00/10g
Yield:140-75-0 91%
Reaction Conditions:
with p-tolyl phenylacetate in dichloromethane at 46; for 5 h;Temperature;
Steps:
1 A method for the synthesis of fluoxylated amines from astroxazole intermediates, comprising the steps of:
In the installation of a stirrer,In the reaction vessel of the reflux condenser,A solution of 0.33 mol of N- (4-fluorobenzyl) phthalimide, 180 ml of a 25% methylene chloride solution,Mass fraction37%Of 0.39 mol of p-cresyl ester of phenylacetic acid,Control the stirring speed at 170rpm, raise the temperature of the solution to 46 , reflux reaction 5h;B, add 380ml of 28% potassium bisulfite solution, reduce the temperature of the solution to 15 ° C, add the mass fraction of 40% sodium nitrate solution 280ml, control the stirring speed at 290rpm, pumping, the filtrate by adding the mass fraction for52% of 2,6-dichloro-4-nitrophenol solution 300ml, with the mass fraction of 59% isopropanol solution extracted 8 times, combined to mentionTake the liquid, the mass fraction of 35% potassium bromide solution washing, anhydrous potassium carbonate dehydrating agent dehydration, filtration, 0.83kPa vacuum distillation,The fractions of 60-67 ° C were collected and recrystallized from a 76% acetonitrile solution to give a solution of p-fluorobenzylamine 37.3g 91%
References:
CN106008229,2016,A Location in patent:Paragraph 0024; 0025; 0026; 0027
459-57-4
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932724-63-5
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140-75-0
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100-46-9
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134227-41-1
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$111.00/250mg
824-75-9
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140-75-0
474 suppliers
$10.00/10g
459-57-4
617 suppliers
$6.00/25g
140-75-0
474 suppliers
$10.00/10g
134227-41-1
39 suppliers
$111.00/250mg
1194-02-1
525 suppliers
$6.00/10g
140-75-0
474 suppliers
$10.00/10g