4-Fluorobenzoic acid synthesis
- Product Name:4-Fluorobenzoic acid
- CAS Number:456-22-4
- Molecular formula:C7H5FO2
- Molecular Weight:140.11
459-56-3
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456-22-4
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Yield:456-22-4 97%
Reaction Conditions:
with diethylene glycol dimethyl ether at 70; for 0.5 h;Sonication;
Steps:
23 Example 23: Preparation of 4-fluorobenzoic acid:
In a 10 mL round bottom flask, 0.63 g of 4-fluorobenzyl alcohol and 2 g of diethylene glycol dimethyl ether were sequentially added.The resulting mixture was subjected to ultrasonic irradiation at 40 kHz/30 W/70 ° C for 30 minutes in an ultrasonic reaction apparatus.Diethylene glycol dimethyl ether was removed under reduced pressure and recrystallized to give 0.67 g of 4-fluorobenzoic acid, yield 97%.
References:
CN108467342,2018,A Location in patent:Paragraph 0142; 0143
352-32-9
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456-22-4
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53458-16-5
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456-22-4
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124-38-9
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460-00-4
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456-22-4
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124-38-9
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225916-39-2
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456-22-4
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