4-Fluorophenyl acetate synthesis
- Product Name:4-Fluorophenyl acetate
- CAS Number:405-51-6
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
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405-51-6
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Yield: 95.4%
Reaction Conditions:
with sodium acetate;acetic anhydride;sodium hydrogencarbonate in water;benzene
Steps:
R.1 4-Fluorophenyl acetate
REFERENCE EXAMPLE 1 4-Fluorophenyl acetate 4-Fluorophenol (112.1 g, 1.0 mole), sodium acetate (68.89 g, 0.74 mole) and acetic anhydride (107.6 g, 1.05 mole) were mixed in benzene (220 ml) with stirring and heated under reflux for 2 hours. After cooling, water (500 ml) and sodium bicarbonate (100 g, 1.19 mole) were added to the reaction mixture and the mixture was stirred. The mixture was allowed to stand to separate into layers and the aqueous layer was extracted with benzene (500 ml). The organic layers were combined, dried over anhydrous sodium sulfate and distilled to obtain the title compound (147 g, 95.4%), b.p. 84°-86° C./16 mmHg.
References:
Shionogi & Co., Ltd. US4780471, 1988, A
371-41-5
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$8.00/25g
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405-51-6
195 suppliers
$8.00/5g