4-Hydroxy-3-methoxybenzonitrile synthesis
- Product Name:4-Hydroxy-3-methoxybenzonitrile
- CAS Number:4421-08-3
- Molecular formula:C8H7NO2
- Molecular Weight:149.15
121-33-5
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$9.00/1g
4421-08-3
159 suppliers
$6.00/5g
Yield:4421-08-3 99%
Reaction Conditions:
with phenoxyamine hydrochloride in methanol;aq. phosphate buffer;water-d2; pH=6.5 at 60; for 8 h;
Steps:
1.1.17 General procedure for the formation of nitriles
General procedure: To a 7mL vial, aldehyde (1 equiv) and O-phenylhydroxylamine hydrochloride (H2NOPh) (1.2 equiv) were dissolved in 4:1 of methanol:0.5M sodium phosphate pH 6.5 to the final concentration of 0.1M. The reaction was stirred at 60°C until the changes of starting materials could not be observed (monitored by TLC). Then, the reaction mixture was cooled to room temperature and extracted with 3mL CH2Cl2 a total of 5 times. The combined organic layer was dried over Na2SO4 and concentrated by rotary evaporator. The crude product was purified by silica column chromatography.
References:
Brichacek, Matthew;Cheewawisuttichai, Thamrongsak;Hurst, Robert D. [Carbohydrate Research,2021,vol. 502,art. no. 108282]
2874-33-1
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$49.00/5g
4421-08-3
159 suppliers
$6.00/5g
306-08-1
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$10.00/1g
4421-08-3
159 suppliers
$6.00/5g
1196-92-5
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$544.00/500g
4421-08-3
159 suppliers
$6.00/5g
2024-83-1
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$13.43/1gm:
17345-61-8
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$10.00/5g
4421-08-3
159 suppliers
$6.00/5g