4-Methyl-5-thiazolylethyl acetate synthesis
- Product Name:4-Methyl-5-thiazolylethyl acetate
- CAS Number:656-53-1
- Molecular formula:C8H11NO2S
- Molecular Weight:185.24
![2(3H)-Thiazolethione, 5-[2-(acetyloxy)ethyl]-4-Methyl-](/CAS/GIF/14066-76-3.gif)
14066-76-3
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656-53-1
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$10.00/5g
Yield:656-53-1 5.948 kg
Reaction Conditions:
with hydrogenchloride;dihydrogen peroxide in water at 50;Industrial scale;Temperature;
Steps:
1-3
At room temperature, put 8.11 kg 2-mercapto-4-methyl-5-(β-acetoxyethyl)-thiazole into a 100L reactor,Add 30L and 5L of 36% concentrated hydrochloric acid, and use a vacuum pump to inhale 36L of 35% hydrogen peroxide in five batches.Raise the temperature to 50°C, after the detection reaction is completed, cool, add sodium hydroxide to adjust the pH to neutral,Add sufficient sodium sulfite to remove excess hydrogen peroxide, extract with dichloromethane, and evaporate to dryness under reduced pressure to obtain 5.948Kg of 4-methyl-5-(β-acetoxyethyl)-thiazole with a content of 99%.
References:
Kunshan Yaxiang Flavors Co., Ltd.;Chen Qing;Zhou Junxue;Qiang Jiankang;Tang Jiangang;Li Xinye;Tang Huaxue;Liu Tianjin CN111635375, 2020, A Location in patent:Paragraph 0016; 0019; 0021; 0024; 0026; 0029
13051-49-5
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656-53-1
322 suppliers
$10.00/5g