5-(2-Hydroxyethyl)-4-methylthiazole synthesis
- Product Name:5-(2-Hydroxyethyl)-4-methylthiazole
- CAS Number:137-00-8
- Molecular formula:C6H9NOS
- Molecular Weight:143.21
656-53-1
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137-00-8
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Yield:137-00-8 100%
Reaction Conditions:
with water;sodium hydroxide in toluene;Industrial scale;
Steps:
1-3
At room temperature, put 5.948 kg 4-methyl-5-(β-acetoxyethyl)-thiazole into a 100L reactor,Add 50L of toluene to dissolve, add 1.54kg of sodium hydroxide and add 10L of water, stir until the reaction is complete,Adjust the pH to slightly acidic, extract with dichloromethane, and distill under reduced pressure to obtain crude 4-methyl-5-(β-hydroxyethyl)-thiazole, which is purified by distillation to obtain 4.3 kg of 100% pure product.
References:
CN111635375,2020,A Location in patent:Paragraph 0016; 0020-0021; 0025-0026; 0030
13045-13-1
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115-08-2
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![Thiazole, 5-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-](/CAS/20210305/GIF/273939-32-5.gif)
273939-32-5
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137-00-8
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$8.00/10g
406727-23-9
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137-00-8
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