4-Nitrobiphenyl synthesis
- Product Name:4-Nitrobiphenyl
- CAS Number:92-93-3
- Molecular formula:C12H9NO2
- Molecular Weight:199.21
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Yield:92-93-3 95%
Reaction Conditions:
with sodium nitrate in dichloromethane for 1 h;Reflux;regiospecific reaction;
Steps:
General procedure for the nitration of aromatic compounds
General procedure: A mixture of aromatic compound (1 mmol), sodium nitrate(1 mmol) and SO3H-functionalized magnetic core/shell nanocatalyst (0.1 mmol) was pulverized in a mortar at room temperature for an appropriate time. The reaction was monitored by thin-layer chromatography (TLC). After completion of the reaction, CH2Cl2 (5.0 mL) was then added to the mixture and filtered. Evaporation of the solvent followed by recrystallization or column chromatography on silicagel of the crude product gave the corresponding nitratedcompounds in good to excellent yields. The nanocatalyst was simply separated from the reaction mixture by using anexternal magnet, washed with methanol/diluted HCl solutionand then dried in an oven at 60 °C. Before reusing the recycled catalyst, it was weighted in any cycle, and after that, it was reused in subsequent runs. Furthermore, fresh catalyst was added to reciprocate decreased mass loss, if it was considerable.
References:
Maleki, Ali;Aghaei, Morteza;Paydar, Reza [Journal of the Iranian Chemical Society,2017,vol. 14,# 2,p. 485 - 490]
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