4-Nitrophenyl isocyanate synthesis
- Product Name:4-Nitrophenyl isocyanate
- CAS Number:100-28-7
- Molecular formula:C7H4N2O3
- Molecular Weight:164.12
Yield:100-28-7 100%
Reaction Conditions:
with triethylamine in dichloromethane at 25;
Steps:
1 Synthesis of Compound 1
To the reaction flask were added 138 g (1 mol) of p-nitroaniline, 110 g (lmol) of triethylamine, 2000 ml of dichloromethane, A solution of 296 g (lmol) of triphosgene in 2000 ml of methylene chloride was added dropwise at 25 ° C at room temperature, and the reaction was continued at that temperature for 3 to 5 hours. The HPLC reaction was followed until the nitroaniline reaction was complete, 3000 ml of water was added, the layers were separated, the organic phase was concentrated and distilled under reduced pressure to give 164 g of the compound 1 was obtained in a molar yield of 100%.
References:
Jiangnan University;Song, Xiaoqing CN104387383, 2016, B Location in patent:Paragraph 0035; 0040; 0041
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