5-Amino-1-pentanol synthesis
- Product Name:5-Amino-1-pentanol
- CAS Number:2508-29-4
- Molecular formula:C5H13NO
- Molecular Weight:103.16
(1) Synthesize 2-hydroxytetrahydropyran: weigh 40g 3,4-dihydro-2H-pyran, 360g of deionized water was added into 600mL reaction kettle, sealed the kettle, replaced with N2 for 3 times and then filled the pressure system of 3MPa, warmed up to 60 ℃, and
694-54-2
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2508-29-4
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$11.00/5g
Yield:2508-29-4 93%
Reaction Conditions:
with ammonium hydroxide;hydrogen in water at 80; under 15001.5 Torr; for 6 h;Pressure;Temperature;
Steps:
1-7 (3) 2-hydroxytetrahydropyran reductive amination
The reaction raw material of the step (1) of this example was distilled under reduced pressure to a 2-hydroxytetrahydropyran having a purity of 96% by weight.62.5 g of the purified 2-hydroxytetrahydropyran was weighed, and 237.5 g of a 25% strength aqueous ammonia solution and a 20 wt% 2-hydroxytetrahydropyranium aqueous reaction liquid were added.The reaction solution and 4 g of the reduction activated catalyst were added to a 600 mL reaction vessel.Reacted at 2MPa H2 pressure 80 ° C for 6h,The reaction solution was analyzed by gas chromatography for the conversion of 2-hydroxytetrahydropyran to 100%.The yield of 5-amino-1-pentanol was 93%.The purity of the product after distillation under reduced pressure is 97%.
References:
Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute;Huang Zhiwei;Chen Jing;Xia Chungu;Li Xuemei;Tian Junying;Kang Haixiao CN108947851, 2018, A Location in patent:Paragraph 0047; 0052; 0056; 0060; 0064; 0068; 0071
111-29-5
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462-94-2
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2508-29-4
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4795-29-3
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2508-29-4
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617-89-0
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2508-29-4
216 suppliers
$11.00/5g