5-Chloronicotinic acid synthesis
- Product Name:5-Chloronicotinic acid
- CAS Number:22620-27-5
- Molecular formula:C6H4ClNO2
- Molecular Weight:157.55
20825-98-3
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$39.00/1g
22620-27-5
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$6.00/250mg
Yield:-
Reaction Conditions:
with sodium hydroxide;water at 60; for 1 h;
Steps:
332 Preparation 332
To 5-chloronicotinate(10. 5 g) was added 1NNaOH (84.9 mL) at ambient temperature. The mixture was heated at60° C for 1 hour. The reaction mixture was adjusted to pH 4-5 withHCI. The precipitate was filtered to give 5-chloronicotinic acid (6.9 g) a colorless solid. H NMR (300 MHz, DMSO-d6)δ 8.30(1H, dd, J = 3 Hz), 8.88(1H, d, J = 3 Hz), 9.01 (1H, d, J = 3 Hz), 13.8(1H, br s). 5-chloronicotinic acid 'H NMR (300 MHz, DMSO-d6) δ 8.30 (1H, dd, J = 3,3 Hz), 8.88 (1H, d, J = 3 Hz), 9.01 (1H, d, J = 3 Hz), 13.8 (1H, br s).
References:
FUJISAWA PHARMACEUTICAL CO., LTD. WO2004/63197, 2004, A1 Location in patent:Page 253
41667-95-2
402 suppliers
$6.00/1g
22620-27-5
214 suppliers
$6.00/250mg