5-Chloropyridine-2-boronic acid synthesis
- Product Name:5-Chloropyridine-2-boronic acid
- CAS Number:652148-91-9
- Molecular formula:C5H5BClNO2
- Molecular Weight:157.36
40473-01-6
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$5.00/1g
652148-91-9
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$34.00/250mg
Yield: 36%
Reaction Conditions:
Stage #1:2-Bromo-5-chloro-pyridine with n-butyllithium in tetrahydrofuran at -78;
Stage #2: with Triisopropyl borate in tetrahydrofuran at -78 - 20;
Stage #3: with sodium hydroxide in tetrahydrofuran;water
References:
Bouillon, Alexandre;Lancelot, Jean-Charles;Santos, Jana Sopkova De Oliveira;Collot, Valérie;Bovy, Philipppe R.;Rault, Sylvain [Tetrahedron,2003,vol. 59,# 50,p. 10043 - 10049]