1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL synthesis
- Product Name:1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL
- CAS Number:5334-29-2
- Molecular formula:C11H7ClN4O
- Molecular Weight:246.65
64-18-6
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51516-67-7
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5334-29-2
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$117.00/1mg
Yield:5334-29-2 73%
Reaction Conditions:
for 12 h;Reflux;
Steps:
5.1.2. General procedure for preparing 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones (13-18)
General procedure: A mixture of 5-amino-1-phenyl-1H-pyrazole-4-carbonitriles (7-12)(0.01 mol) and 20 mL of formic acid was stirred and allowed to reflux for 12 h. The reaction mixture was poured into 50 mL of ice-cold water. The precipitate was collected by filtration and washed with water to produce 13-18 in 68-89% yield.
References:
Feitosa, Livia M.;da Silva, Edson R.;Hoelz, Lucas V.B.;Souza, Danielle L.;Come, Julio A.A.S.S.;Cardoso-Santos, Camila;Batista, Marcos M.;Soeiro, Maria de Nazare C.;Boechat;Pinheiro, Luiz C.S. [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3061 - 3069]
50427-79-7
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123-06-8
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5334-29-2
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$117.00/1mg
1073-69-4
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5334-29-2
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