6-(Chloromethyl)uracil synthesis
- Product Name:6-(Chloromethyl)uracil
- CAS Number:18592-13-7
- Molecular formula:C5H5ClN2O2
- Molecular Weight:160.56
22126-44-9
18592-13-7
In a 250 mL three-necked flask, 6-(hydroxymethyl)uracil (11.5 g, 0.081 mol) was added, followed by 115 mL of dichloromethane, thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N,N-dimethylformamide in sequence. The reaction mixture was heated to reflux temperature and stirred continuously for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration, washed with dichloromethane and dried to give 6-(chloromethyl)uracil (11.8 g, 90.8% yield).
22126-44-9
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18592-13-7
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Yield:18592-13-7 90.8%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide in dichloromethane for 2 h;Reflux;Reagent/catalyst;
Steps:
9.3
In a 250 mL three-necked flask,Compound 2 (11.5 g, 0.081 mol) was added,Then, 115 mL of dichloromethane was added successively,Thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N, N-dimethylformamide,Add the temperature to reflux and stir the reaction for 2 hours.Cooled to room temperature,Filter,Dichloromethane wash,dry,11.8 g of 6-chloromethyluracil was obtained in a yield of 90.8%.
References:
Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.;Jiang Hong;Lv Chuantao;Ma Chonglei;Lin Hongjie;Hao Lianfeng;Liu Yongyong;Lu Jingjing CN106831607, 2017, A Location in patent:Paragraph 0049
183205-42-7
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18592-13-7
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89639-37-2
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638-07-3
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57-13-6
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18592-13-7
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626-48-2
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18592-13-7
277 suppliers
$7.00/250mg