6-Fluoronicotinic acid synthesis
- Product Name:6-Fluoronicotinic acid
- CAS Number:403-45-2
- Molecular formula:C6H4FNO2
- Molecular Weight:141.1
2369-19-9
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403-45-2
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$4.00/1g
Yield:403-45-2 11.8 g
Reaction Conditions:
with potassium permanganate;potassium hydroxide in water at 95; for 5 h;Reagent/catalyst;
Steps:
1-5
Example 1:In a 500mL three-necked flask, add 11.1g (0.1mol) 2-fluoro-5-methylpyridine, add 250mL of water, start mechanical stirring, add 31.6g (0.2mol) KMnO4 and 5.6g (0.1mol) KOH successively, oil bath Heat to 95°C, react for 5h, filter while hot, and collect the filtrate. After the filtrate drops to room temperature, adjust the pH value to 2 to 4 with concentrated hydrochloric acid, and solids are precipitated out and filtered; the filtrate is extracted twice with dichloroethane. The filtered solid and the extracted oil are mixed and rotary evaporated to obtain 11.8 g of off-white solid, which is 2-fluoro-5-carboxylic acid pyridine (melting point: 275-278°C).
References:
CN112358442, 2021, A Location in patent:Page/Page column 4; 5
59-67-6
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403-45-2
286 suppliers
$4.00/1g
1603-41-4
556 suppliers
$7.00/25g
403-45-2
286 suppliers
$4.00/1g