Benzyl salicylate synthesis
- Product Name:Benzyl salicylate
- CAS Number:118-58-1
- Molecular formula:C14H12O3
- Molecular Weight:228.24
54-21-7
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118-58-1
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Yield:118-58-1 96.36%
Reaction Conditions:
with potassium fluoride at 150; for 2 h;Reagent/catalyst;Temperature;
Steps:
4
A new method of solid-liquid phase transfer catalytic synthesis of benzyl salicylate: take sodium salicylate 320.22g (2mol), benzyl chloride 126.6g (1mol), PEG-4000 (0.1mol) and potassium fluoride (0.001mol), Add neck round bottom flask at a temperature of 150 reaction 2h, after completion of the reaction, water was added to make the reaction liquid stratification, the organic layer separated, the organic layer was washed with distilled water again, and then mass percent concentration of 5% NaHCO3Aqueous solution was washed twice with distilled water and washed twice.Followed by dehydration and vacuum distillation, collecting 164-165 / 725Pa of distillate, benzyl salicylate product, the product is a colorless transparent liquid, low temperature as white needles.Detected by gas chromatography, the purity 99.54%, product yield was 96.36%.Benzyl chloride conversion rate of 99.19%, 97.15% selectivity of the reaction.
References:
Foshan Nanhai Zhongnan Pharmaceutical & Chemical Factory;Xiao, guoqiang;chen, kangqing CN104557551, 2016, B Location in patent:Paragraph 0023; 0024
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100-44-7
642 suppliers
$13.50/250G
69-72-7
1345 suppliers
$5.00/10g
118-58-1
494 suppliers
$8.00/25g