dimethyl(2-phenoxyethyl)amine synthesis
- Product Name:dimethyl(2-phenoxyethyl)amine
- CAS Number:13468-02-5
- Molecular formula:C10H15NO
- Molecular Weight:165.23
Yield: 86%
Reaction Conditions:
with potassium hydroxide in ethanol;water at 55 - 60; for 4 h;Reagent/catalyst;
Steps:
1.1 First Step
The phenol 94g (1mol), potassium hydroxide 117.6g (2.1mol) was added 600ml ethanol and stirred to dissolve, temperature at 55 ~ 60 reaction slowly added dropwiseN, N- dimethyl-chloroethane hydrochloride 158g (1.1mol, was dissolved in 300g water), the addition was complete reaction was continued for 4 hours; the reaction was completed, recovering ethanol, then extracted twice with dichloromethane, combined, washed with water and concentrated to give an oil 142g XI, a yield of 86.0%;
References:
Weihai Di Su Pharmaceutical Co., Ltd.;Wu, Ronggui;Jiang, Kai;An, Donghua;Cui, Yangyang;Men, Lianbin CN105985257, 2016, A Location in patent:Paragraph 0007; 0014
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