DL-Alanine synthesis
- Product Name:DL-Alanine
- CAS Number:302-72-7
- Molecular formula:C3H7NO2
- Molecular Weight:89.09
Yield:302-72-7 90.8 %Spectr. ，849585-22-4 9.2 mg
Reaction Conditions:
with [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl];ammonium formate in methanol at 37; for 6 h;chemoselective reaction;Solvent;
Steps:
General Procedure for Reductive Amination of α-Ketoacids
General procedure: α-Ketoacid (0.2 mmol) and Ir1 (1 mol%) were added to a 1.5-dram vial equipped with amagnetic stir bar in methanol (1 mL). Solid HCOONH4 (2 mmol, 10 equiv.) was added to thevial and the solution was stirred at 37 °C for 6 h. The precipitate was filtered, washed with asmall amount of cold methanol, and dried under vacuum to give the desired α-amino acid.
References:
Nguyen, Dat P.;Sladek, Rudolph N.;Do, Loi H. [Tetrahedron Letters,2020,vol. 61,# 32,art. no. 152196] Location in patent:supporting information
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