Drometrizole synthesis
- Product Name:Drometrizole
- CAS Number:2440-22-4
- Molecular formula:C13H11N3O
- Molecular Weight:225.25
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Yield:2440-22-4 99.4%
Reaction Conditions:
with hydrogen;sodium hydroxide in ethanol;water at 80; under 18751.9 Torr;Autoclave;Reagent/catalyst;
Steps:
2 1, the experimental steps
The compound represented by the formula (I-1) is dissolved in a solvent (a volume ratio of ethanol to water is 1:1) at a molar ratio of 1:2 with sodium hydroxide, and the raw material solution is set to 700 mL with a mass concentration of 20%. To the autoclave; add 5% of the mass of the compound represented by the formula (I-1) to the raw material solution, pass hydrogen gas, keep the hydrogen pressure at 2.5 MPa, and heat to a temperature of 80°C to start the reaction; High-performance liquid chromatography was used to monitor the reaction solution in real time. After the reaction was completed, it was cooled to room temperature, hydrogen was discharged to recover normal pressure, and the catalyst was recovered. Hydrochloric acid was added dropwise to adjust the reaction solution to neutrality. The precipitate was filtered and washed with hot water. Drying, Benzotriazole UV Absorber of Formula (II-1)
References:
CN107935951,2018,A Location in patent:Paragraph 0044-0057
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