一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Estramustine
2998-57-4

Estramustine synthesis

2synthesis methods
-

Yield: 94.1%

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 40; for 4.5 h;

Steps:


4.00g (14.7mmol)1,3,5(10)-triene-3,17β-estradiol(The compound represented by formula 14) was dissolved in 150.0 mL of dichloromethane,Add 2.97g (29.4mmol) of triethylamine,And 0.19g (1.5mmol) 4-dimethylaminopyridine/DMAP,Stir at room temperature for 10 minutes;Dissolve 4.51g (22.1mmol) of N,N-bis(2-chloroethyl)carbamoyl chloride in 50.0mL of dichloromethane,Slowly add dropwise to the above reaction solution,The dripping is completed within 30 minutes,Continue to stir and react for 1 hour,Then, the reaction solution was transferred to a water bath at 40°C for 3 hours to keep warm. TLC detection reaction shows that the reaction is complete,Stop the reaction,Cool the reaction liquid to room temperature,Add 50.0mL distilled water,Adjust the pH of the reaction solution between 5-6 with 10% hydrochloric acid solution under stirring,Let stand for layering,Separate the organic layer,The aqueous layer was extracted with dichloromethane (50.0mL×3),Combine the organic phases,The solvent was distilled off under reduced pressure to obtain a crude off-white solid.Hot ethanol recrystallization6.09g white crystal compound(Compound represented by formula 15), the yield is 94.1%.

References:

Zhou Yayao CN111410677, 2020, A Location in patent:Paragraph 0047; 0048; 0049

Estramustine Related Search:

曲水县| 吉木乃县| 安新县| 金沙县| 花垣县| 望奎县| 南召县| 旌德县| 清丰县| 凤城市| 淮北市| 石棉县| 广东省| 昆山市| 沈阳市| 徐汇区| 崇信县| 察隅县| 顺平县| 临高县| 永定县| 五原县| 通城县| 报价| 明星| 岱山县| 九龙坡区| 营山县| 伊金霍洛旗| 安达市| 黎平县| 天台县| 汶上县| 榆中县| 永吉县| 江西省| 酒泉市| 青阳县| 和平县| 玉树县| 怀来县|