Ethyl 2,3-dicyanopropionate synthesis
- Product Name:Ethyl 2,3-dicyanopropionate
- CAS Number:40497-11-8
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
105-56-6
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40497-11-8
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$38.00/5G
Yield:40497-11-8 77%
Reaction Conditions:
with paraformaldehyde in ethanol;water
Steps:
1 Preparation of ethyl 2,3-dicyanopropionate.
EXAMPLE 1 Preparation of ethyl 2,3-dicyanopropionate. Potassium cyanide (13.0 g, 0.2M) was stirred in absolute ethanol and ethyl cyanoacetate (22.6 g, 0.2M) and paraformaldehyde (6.0 g, 0.2m) were added at ambient temperature. After 5 minutes the white suspension was heated under reflux conditions for 12 minutes, and the orange solution was evaporated to dryness in vacuo at below 25° C. to give a buff solid. The solid (the potassium salt) was dissolved in water (400 ml), acidified to pH 5 with 2M hydrochloric acid solution, giving a red oil. This mixture was extracted with dichloromethane and the extracts dried and evaporated to dryness in vacuo to give the title compound as a red oil (23.5 g), 1 H NMR (CDCl3) d 4.3 (2H, q), 3.95 (1H, t), 3.0 (2H, d), 1.35 (3H, t); identical with an authentic sample. Distilled material had b.p. 132-136° C. at 0.5mmHg. Yield: 77%.
References:
Rhone-Poulenc Agro US6133432, 2000, A
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105-56-6
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40497-11-8
228 suppliers
$38.00/5G
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50-00-0
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40497-11-8
228 suppliers
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7085-85-0
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40497-11-8
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105-56-6
458 suppliers
$10.00/5ml
40497-11-8
228 suppliers
$38.00/5G