ChemicalBook CAS DataBase List Fenbendazole

Fenbendazole synthesis

5synthesis methods

Product Name:Fenbendazole
CAS Number:43210-67-9
Molecular formula:C15H13N3O2S
Molecular Weight:299.35

Fenbendazole is a benzimidazole anthelmintic, which has high anthelmintic activity against gastrointestinal nematodes adults and larvae, but also has good effects on reticulate nematodes, fascioli and tapeworms. The synthetic method is that 5-Chloro-2-nitroaniline reacts with benzenethiol to obtain 5-phenylthio-2-nitroaniline, which is reduced by ferrous sulfate-iron powder to obtain 3-phenylthio-o-phenylenediamine and finally reacts with S-methyl-cyanamide methyl ester via cyclization to give benthiobenzimidazole.

1635-61-6 Synthesis

1635-61-6
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43210-67-9
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: K₂CO₃ / dimethylformamide / 6 h / Heating
2.1: H₂ / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H₂O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H₂O; ethanol / 24 h / 95 °C

References:

Cortes, Eduardo Cortes;Mendoza, Rafael Sosa;Gutierrez, Maximiliano Santibanez;De Cortes, Olivia Garcia-Mellado [Journal of Heterocyclic Chemistry,2004,vol. 41,# 2,p. 273 - 276]

Carbamic acid, N-[6-(phenylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester, (+)-

122063-23-4
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43210-67-9
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References

43156-47-4 Synthesis

43156-47-4
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43210-67-9
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108-98-5
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$21.10/10g

43210-67-9
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$5.00/100mg

References

930-69-8
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$45.00/500mg

43210-67-9
609 suppliers
$5.00/100mg

References

Fenbendazole Related Search:

Methimazole Benzimidazole Imidazole Methylparaben Methyl acetate Imidocarb dipropionate Albendazole Oxfendazole Oxibendazole 2-Aminobenzimidazole

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Fenbendazole synthesis

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