ISOPROPYL TRIFLUOROACETATE synthesis
- Product Name:ISOPROPYL TRIFLUOROACETATE
- CAS Number:400-38-4
- Molecular formula:C5H7F3O2
- Molecular Weight:156.1
Yield: 92.9%
Reaction Conditions:
with potassium fluoride at 45; for 3.5 h;Large scale;
Steps:
2 Example 2
In a reaction kettle with a stirrer, add 12 kg of isopropanol. With stirring,Slowly add 5.8 kg of potassium fluoride, and mix the two to obtain a mixture of isopropanol and potassium fluoride.Transfer the mixture of isopropanol and potassium fluoride to a closed reactor with a stirrer.Start stirring,11.6 kg of trifluoroacetyl fluoride gas is passed into a mixture of isopropanol and potassium fluoride for reaction,The reaction temperature was controlled at 45 ° C and the reaction time was controlled at 3.5 hours.After the reaction is completed, the reaction product is filtered to remove solid KHF2.The filtrate was transferred to a rectification column for rectification to obtain 14.5 kg of isopropyl trifluoroacetate (yield: 92.9%).KHF2 removed, which is a solid, neutralized with KOH after dissolving in water,All are converted into KF, which is recovered and reused as raw material after dewatering and drying.
References:
Sanming Haisifu Chemical Co., Ltd.;Cao Wei;Lv Tao;Xie Weidong;Zhang Wei CN104370739, 2016, B Location in patent:Paragraph 0021-0022
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