L-Serinamide hydrochloride synthesis
- Product Name:L-Serinamide hydrochloride
- CAS Number:65414-74-6
- Molecular formula:C3H9ClN2O2
- Molecular Weight:140.57
5680-80-8
65414-74-6
General procedure for the synthesis of (S)-2-amino-3-hydroxypropionamide hydrochloride from L-serine methyl ester hydrochloride: 3.5 g (0.0225 mol) of L-serine methyl ester hydrochloride was dissolved in 100 mL of ammonia and the reaction was stirred for 48 hours at room temperature. Upon completion of the reaction, the ammonia was removed by distillation under reduced pressure, and a small amount of dilute hydrochloric acid was added to the residue to dissolve it, followed by freeze-drying of the solution to give 2.8 g of a light yellow solid product, L-serine hydrochloride, in 87.5% yield.
5680-80-8
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65414-74-6
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Yield: 87.5%
Reaction Conditions:
with ammonium hydroxide at 20; for 48 h;
Steps:
4.1 Synthesis of 4.1L-Selinamide Hydrochloride
Dissolve 3.5 g (0.0225 mol) of L-serine methyl ester hydrochloride in 100 mlIn ammonia water, the reaction was stirred for 48 h under room temperature. The reaction was stopped, ammonia was distilled off under reduced pressure, a small amount of diluted hydrochloric acid was added to dissolve the residue, and the residue was freeze-dried to obtain 2.8 g of L-serine hydrochloride as a pale yellow solid with a yield of 87.5%.
References:
The Chinese People's Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute;Zhong Bohua;Zhang Ping;He Xinhua;Shi Weiguo;Fan Shiyong;Yao Yishan;Jia Hongxin CN103804341, 2018, B Location in patent:Paragraph 0049; 0051; 0052