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ChemicalBook CAS DataBase List Lincomycin
154-21-2

Lincomycin synthesis

2synthesis methods
Lincomycin, 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidincarboxamido)-1-methylthio-D-erythro-α-D-galacto-octopyranoside (32.5.1), is the first lincosamide that has found use in clinical practice, and which was isolated in 1962 from the culture liquid of the activity of the actinomycete Streptomyces lincolnensis.
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: pyridine / 8 h / 2 - 20 °C
2: acetic acid / methanol / 18 h / 30 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 h / 30 °C
4: potassium carbonate / methanol / 20 h / 130 °C

References:

Tianjin Kelun Pharmaceutical Co., Ltd.;Li Faguang;Wang Qianqian;Huang Chang;Wang Yufen;Wang Linlin;Huo Xianghong;Wang Qi;Wang Lichun;Wang Jingyi CN110606865, 2019, A

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