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ChemicalBook CAS DataBase List Linuron
330-55-2

Linuron synthesis

3synthesis methods
Linuron is commercially produced through a straightforward synthesis typical of phenylurea herbicides. The process begins with the reaction of 3,4-dichloroaniline with dimethylcarbamoyl chloride or a similar methylating agent to form the urea linkage. This intermediate is then reacted with methanol to introduce the methoxy group, yielding the final compound: 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea. The synthesis involves standard organic reactions under controlled conditions using solvents and reagents that ensure high purity and herbicidal efficacy.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
2: aq. NaOH / methanol

References:

Scherer,O. et al. [Angewandte Chemie,1963,vol. 75,p. 851 - 854]

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