Lonidamine synthesis
- Product Name:Lonidamine
- CAS Number:50264-69-2
- Molecular formula:C15H10Cl2N2O2
- Molecular Weight:321.16
![1H-Indazole-3-methanol, 1-[(2,4-dichlorophenyl)methyl]-](/CAS/20210305/GIF/920019-58-5.gif)
920019-58-5
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50264-69-2
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Yield:50264-69-2 80%
Reaction Conditions:
with chromium(VI) oxide;sulfuric acid in acetone at 20; for 24 h;
Steps:
4 Example 4, Synthesis of lonidamine:
CrO3 (27 mg, 0.27 mmol) was dissolved in 1.5 M H2SO4 (0.5 mL) at room temperature,A solution of compound 7 (18 mg, 0.06 mmol) in acetone (1.5 mL) was added dropwise,Room temperature reaction for 24 hours,Dichloromethane extraction,Organic phase with water,Anhydrous MgSO4 dried,The solvent was distilled off under reduced pressure,The chromatographic separation of lonidamine (15 mg, 80% yield).
References:
CN106316958,2017,A Location in patent:Paragraph 0102; 0104; 0108; 0109
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