Methyl 3,5-dimethoxybenzoate synthesis
- Product Name:Methyl 3,5-dimethoxybenzoate
- CAS Number:2150-37-0
- Molecular formula:C10H12O4
- Molecular Weight:196.2
Yield:2150-37-0 97.1%
Reaction Conditions:
with potassium carbonate in acetone at 60; for 3 h;Inert atmosphere;
Steps:
1.1 Synthesis 1, 3, 5 -methoxybenzoic acid methyl ester (B - 1a)
B (200 g, unitunitunito, 1.19 μM eq.), anhydrous potassium carbonate (1 .00, unitunitunit, 3.57 μM 493 g eq.) were added to 3L three-port round bottom reaction flasks, and acetone (2L) was added for mechanical stirring, and 450 g bubbled 3.57 μM out 3 .00, unitarily , heated and refluxed for 3h, 60 °C TLC monitoring the 1 reaction (PE:EA=2: 3 .00).]The reaction mixture was cooled 25 °C, filtered, washed with acetone, filtered and the mother liquor, concentrated under reduced pressure, and the residual oil was added with unitine 200 ml) heavy crystals. (The product was filtered, and vacuum dried to give white solid B - 1a (226 97.1% g
References:
Guangdong Zhongke Pharmaceutical Co., Ltd.;Wang Wei;Wang Yandong;Lu Yongzhang;Tan Jinhui CN109988156, 2019, A Location in patent:Paragraph 0091; 0093; 0094 ;0095
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