METHYL BIPHENYL-2-CARBOXYLATE synthesis
- Product Name:METHYL BIPHENYL-2-CARBOXYLATE
- CAS Number:16605-99-5
- Molecular formula:C14H12O2
- Molecular Weight:212.25
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16605-99-5
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Yield: 85%
Reaction Conditions:
with potassium carbonate in acetonitrile at 50; for 8 h;
Steps:
5.0 Exact experimental procedure for the synthesis of 4-methyl-1,1'-biphenyl (3c)
General procedure: The acetonitrile (3 mL) were added in to the oven dried 25mL R.B.F containing compound 1a (54.07mg, 0.5 mmol), followed by addition of K2CO3 (152.02 mg, 2.2 equiv), catalyst (2.39 mg, 2 mol% 44.48w/v), compound 2c (0.55 mmol, 119.91 mg, 1.1 equiv). The reaction mixture was stirred at 50 °C for 16 h, after complete conversion of starting material (indicated by TLC), the solvent was evaporated by rotary evaporator and crude compound was purified by column chromatography (eluent: 2% EA/Hexane) to get the compound 4-methyl-1,1'-biphenyl (3c, 73.08 mg, 87%).
References:
Hegde, Rajeev V.;Ghosh, Arnab;Patil, Siddappa A.;Dateer, Ramesh B. [Tetrahedron,2019,vol. 75,# 52,art. no. 130777] Location in patent:supporting information
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16605-99-5
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$45.00/20mg
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16605-99-5
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$45.00/20mg