ChemicalBook CAS DataBase List METHYL OROTATE

METHYL OROTATE synthesis

5synthesis methods

Product Name:METHYL OROTATE
CAS Number:6153-44-2
Molecular formula:C6H6N2O4
Molecular Weight:170.12

67-56-1

65-86-1

6153-44-2

To a 500 mL three-necked flask was added whey acid (15.6 g, 0.10 mol), followed by 300 mL of anhydrous methanol, stirring and cooling the reaction system to 0°C. Thionyl chloride (10.9 mL, 0.15 mol) was added dropwise, slowly, while maintaining the temperature at 0-5°C. The reaction system was then cooled to 0°C. The reaction system was then cooled to 0°C. The reaction system was then cooled to 0°C. After the dropwise addition, the reaction system was warmed up to reflux and the reaction was continued for 6 hours. Upon completion of the reaction, the reaction mixture was slightly cooled and subsequently dried under vacuum to remove the solvent. To the residue, 50 mL of anhydrous methanol was added and removed with thorough stirring. Next, 150 mL of methyl tert-butyl ether was added and stirred at room temperature for 1 hour. Finally, the solid product was collected by filtration and washed with methyl tert-butyl ether to afford 15.8 g of the target compound, methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate, in 92.9% yield.

67-56-1 Synthesis

67-56-1
793 suppliers
$7.29/5ml-f

65-86-1 Synthesis

65-86-1
454 suppliers
$5.00/100mg

6153-44-2
136 suppliers
$7.00/250mg

Yield: 92.9%

Reaction Conditions:

with thionyl chloride at 0 - 5; for 6 h;Reflux;

Steps:

9.1
In a 500 mL three-necked flask,Add orotic acid(15.6 g, 0.10 mol),Then 300 mL of anhydrous methanol was added,Stirring down to 0 ,Maintain the temperature 0 ~ 5 drop add thionyl chloride(10.9 mL, 0.15 mol),And the temperature was raised to reflux for 6 hours.Slightly cold,Vacuum drying solvent,Add 50 mL of anhydrous methanol to lift off.150 mL of methyl t-butyl ether was added,Stirred at room temperature for 1 hour,Filter,Methyl tert-butyl ether wash.dry,To obtain 15.8 g of compound 1,Yield 92.9%.

References:

Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.;Jiang Hong;Lv Chuantao;Ma Chonglei;Lin Hongjie;Hao Lianfeng;Liu Yongyong;Lu Jingjing CN106831607, 2017, A Location in patent:Paragraph 0047