Orotic acid synthesis
- Product Name:Orotic acid
- CAS Number:65-86-1
- Molecular formula:C5H4N2O4
- Molecular Weight:156.1
626-48-2
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65-86-1
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$5.00/100mg
Yield:65-86-1 92%
Reaction Conditions:
with 2,2'-azobis(isobutyronitrile);oxygen;cobalt(II) acetate;acetic acid at 80; for 15 h;
Steps:
1.a Example 1: Synthesis of 5-nitro-2,6-dioxo-1,3-dihydropyrimidine-4-carboxylic acid
To a 500 ml three-necked flask, 6-methylpyrimidine-2,4 (1H, 3H) -dione (10.0 g,(0.28 g, l.6 mmol), glacial acetic acid (250 mL), oxygen (flow rate: 6-10 m / s), tube diameter (flow rate: 6-10 m / s), AIBN (azobisisobutyronitrile, 0.26 g, l.6 mmol) (T6m2), heated to 80 ° C reaction for 15 hours, after the end of the reaction, into the saturated salt water, vacuum pumping, drying, recrystallization (good solvent chloroform,Poor solvent methanol) gave a white solid, 11.48, in a yield of 92.0%.
References:
Dalian Wanfu Pharmaceutical Co., Ltd.;Sun Qingfa CN106946887, 2017, A Location in patent:Paragraph 0023-0025
461-72-3
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$20.00/25g
298-12-4
472 suppliers
$5.00/25g
65-86-1
454 suppliers
$5.00/100mg
5988-19-2
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$5.00/250mg
65-86-1
454 suppliers
$5.00/100mg
