N-Cyclohexyl-4-methylbenzenesulfonamide synthesis
- Product Name:N-Cyclohexyl-4-methylbenzenesulfonamide
- CAS Number:80-30-8
- Molecular formula:C13H19NO2S
- Molecular Weight:253.36
Yield: 79%
Reaction Conditions:
with phenyltrimethylammonium tribromide in tetrahydrofuran at 30; for 8 h;
Steps:
General experimental procedure (A) for the synthesis of sulfonamides
General procedure: To a well stirred solution of sodium sulfinate(1equiv.) in THF Phenyl Trimethyl ammonium Tribromide (PTAB)(1equiv.) was added and stirred about 5 minutes, The amine (1 equiv.) was then added to the reaction mixture and the reaction mixture was stirred for 6-8 hrs at room temperature. After completion of the reaction which was monitored with TLC, the reaction mixture was quenched with distilled water and extracted with ethyl acetate (3X3ml). The organic fraction was washed with saturated brine solution and dried over oven dried anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. The residual crude mass was then subjected to column chromatography over silica gel, Elution with proper solvent mixture afforded the desired sulfonamide as the pure product.
References:
Sarkar, Debayan;Ghosh, Manoj Kumar;Rout, Nilendri [Tetrahedron Letters,2018,vol. 59,# 24,p. 2360 - 2364] Location in patent:supporting information
