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ChemicalBook CAS DataBase List N-Methyl 3,5-difluoroaniline
470458-51-6

N-Methyl 3,5-difluoroaniline synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: SOCl2, DMF / CH2Cl2 / 4 h / Heating
2: conc. NH4OH / tetrahydrofuran / 0 °C
3: 1) Br2, aq. NaOH / 1) reflux, 2 h, 2) reflux, 2 h
4: LiAlH4 / diethyl ether / 3.5 h / Heating

References:

Florvall, Lennart;Fagervall, Ingrid;Larsson, Lars-Gunnar;Ross, Svante B. [European Journal of Medicinal Chemistry,1999,vol. 34,# 2,p. 137 - 151]

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