N,N-DIDODECYLMETHYLAMINE synthesis
- Product Name:N,N-DIDODECYLMETHYLAMINE
- CAS Number:2915-90-4
- Molecular formula:C25H53N
- Molecular Weight:367.7
7311-30-0
76 suppliers
$21.00/250mg
143-15-7
453 suppliers
$5.00/25g
2915-90-4
102 suppliers
$21.00/1g
Yield: 55%
Reaction Conditions:
in ethanol for 48 h;Reflux;
Steps:
2.3.1 Preparation of N,N-didodecylmethylamine
3.6mL (14mmol) of 16 N-dodecylmethylamine and 6.4mL (27mmol) of 17 1-bromododecane were dissolved in 30mL of absolute 18 EtOH. The mixture was heated to reflux for two days. The solvent was removed under reduced pressure, the residue was dissolved in 19 CHCl3 and washed three times with a saturated aqueous solution of 20 NaHCO3. The organic layer was dried over anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure. The oily residue was purified by chromatography on silica gel (eluent CHCl3) to afford 2.89g of 21 N,N-didodecylmethylamine (yield 55%). 1H NMR (δ CDCl3, 300MHz) ppm: 0.84 (t, 3JHH=9.18Hz, 6H, CH2CH3); 1.16-1.29 (m, 36H, NCH2CH2(CH2)9CH3); 1.54 (m, 4H, NCH2CH2); 2.34 (s, 3H, NCH3); 2.49 (m, 4H, NCH2). 13C NMR (δ CDCl3, 75MHz) ppm: 14.11; 22.69; 27.28; 27.63; 29.36; 29.64; 31.92; 42.31; 57.91
References:
Mauceri, Alessandro;Giansanti, Luisa;Bozzuto, Giuseppina;Condello, Maria;Molinari, Agnese;Galantini, Luciano;Piozzi, Antonella;Mancini, Giovanna [Biochimica et Biophysica Acta - Biomembranes,2019,vol. 1861,# 8,p. 1468 - 1475]
3007-53-2
83 suppliers
$144.00/250mg
112-18-5
417 suppliers
$5.00/25g
112-53-8
498 suppliers
$10.00/5g
2915-90-4
102 suppliers
$21.00/1g
3007-53-2
83 suppliers
$144.00/250mg
112-18-5
417 suppliers
$5.00/25g
2915-90-4
102 suppliers
$21.00/1g
112-53-8
498 suppliers
$10.00/5g
124-40-3
542 suppliers
$18.00/100ml
112-18-5
417 suppliers
$5.00/25g
2915-90-4
102 suppliers
$21.00/1g
3007-31-6
90 suppliers
$64.00/2 g
124-38-9
724 suppliers
$175.00/23402
2915-90-4
102 suppliers
$21.00/1g