Phenyl carbamate synthesis
- Product Name:Phenyl carbamate
- CAS Number:622-46-8
- Molecular formula:C7H7NO2
- Molecular Weight:137.14
1885-14-9
347 suppliers
$10.00/1g
622-46-8
108 suppliers
$33.20/5g
Yield:622-46-8 81.7%
Reaction Conditions:
with triethylamine;aniline in dichloromethane
Steps:
1.a a
a Phenyl N-carbamate Triethylamine (1.11 g, 11.0 mmol) was added to a solution of aniline (1.00 g, 11.0 mmol) dissolved in dichloromethane (20 ml), and phenylchloroformate (1.76 g, 11.0 mmol) was added thereto by dropping. The resulting solution was stirred for 2 hours at the room temperature, washed with distilled water, concentrated and purified by column chromatography to give the titled compound. Yield: 81.7% m.p.: 119~120° C. 1H NMR(CDCl3): δ 5.10(1H,brs), 6.63(1H,dd), 6.67(2H,d), 7.05(1H,m), 7.13(2H,m), 7.46(2H,m), 7.60(2H,m)
References:
Samjin Pharmaceutical Co., Ltd. US2002/111491, 2002, A1
